Yale University;The United States Government as represented by the Department of Veterans Affairs
发明人:
James E. Hansen,Richard H. Weisbart,Philip W. Noble
申请号：
US16676076
公开号：
US20200199255A1
申请日:
2019.11.06
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Antigen binding molecules that bind to the epitope of 3E10, and methods of use thereof are provided. The antigen binding molecule can include, for example, two or more variant single chain variable fragments (scFv) of monoclonal antibody 3E10, wherein the variant scFv has one or more insertions, deletions, or substitutions relative to a corresponding 3E10 scFv, and wherein the molecule can bind, preferably specifically bind, to the epitope of 3E10. Methods of using the antigen binding molecules for treating cancer and viral infections or preventing viral infections are also provided.
