The preset invention provides a method of increasing the effect of an activated-potentiated form of an antibody to an endogenous biological molecule by combining said endogenous biological molecule Mth an activated-potentiated form of an antibody to endothelial NO-synthase. The present invention also provides a pharmaceutical composition comp a) an activated-potentiated form of an antibody to an endogenous biological molecule, and b) an activated-potentiated form of an antibody to NO synthase.
