MYLONAKIS Andreas (US);LIM Florencia (US);ACCESS CLOSURE Inc.
发明人:
MYLONAKIS Andreas (US),LIM Florencia (US)
申请号：
IL24909616
公开号：
IL249096D0
申请日:
2016.11.21
申请国别(地区):
IL
年份:
2017
代理人:
摘要：
A sealant is provided for sealing a puncture through tissue that comprises an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The first section comprises chitosan and at least one additional polymer. The second section may be formed from a solid mass of non-freeze-dried, non-cross-linked hydrogel precursors. The precursors are in an unreactive state until exposed to an aqueous physiological environment, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. The second section may further comprise chitosan. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.
