治療Ｃ型肝炎病毒（ＨＣＶ）之方法农业专利-农业专业知识服务系统

发明人:: BERNSTEIN, BARRY M.,伯斯丁　贝瑞Ｍ,伯斯丁　貝瑞Ｍ,MENON, RAJEEV M.,曼诺　瑞吉夫Ｍ,曼諾　瑞吉夫Ｍ,KHATRI, AMIT,克汉崔　阿米特,克漢崔　阿米特,MENSING, SVEN,曼心　史维,曼心　史維,DUTTA, SANDEEP,都塔　桑迪普,COHEN, DANIEL E.,可汉　丹尼尔Ｅ,可漢　丹尼爾Ｅ,PODSADECKI, TH,伯斯丁贝瑞M,伯斯丁貝瑞M,曼诺瑞吉夫M,曼諾瑞吉夫M,克汉崔阿米特,克漢崔阿米特,曼心史维,曼心史維,都塔桑迪普,可汉丹尼尔E,可漢丹尼爾E

摘要：: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to the subject effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), an inhibitor of cytochrome P450 (e.g., ritonavir), and ribavirin.本發明之特徵為用於治療HCV之無干擾素療法。該治療較佳歷經較短之持續時間，諸如不超過12週。在一個態樣中，該等療法包含向感染HCV之個體投與至少兩種直接作用抗病毒劑及病毒唑。舉例而言，該等療法包含向該個體投與有效量之治療劑1、治療劑2(或治療劑3)、細胞色素P450抑制劑(例如利托那韋)及病毒唑。