COOPER, Matthew,MILLER, David,MACLEOD, Angus,VAN WILTENBURG, Jimmy,THOM, Stephen,ST-GALLAY, Stephen,SHANNON, Jonathan
申请号:
CL2020000029
公开号:
CL2020000029A1
申请日:
2020.01.06
申请国别(地区):
CL
年份:
2020
代理人:
摘要:
F amp; oacute; n refers to the compound of F amp; oacute; rmula (I),Q is selected from O or s; R1 is an unorthodox group; Iacute is an unorthodox group; aroma is an unorthodox group; Aacute is an unorthodox group, including at least one amp; Aacute is a group containing ammonium nitrate; oacute is an unorthodox group; ROM is an unorthodox group, which contains a amp; ocute is an unorthodox group; ROM is an unorthodox group. R2 is a C amp; group; Iacute; click to replace in posici amp; oacute; n amp; alpha;,R2 can be replaced by additional form. 1. The name of the invention is: ADEM amp; oacute; n refers to ADEM amp; Aacute; s refers to salts, solutions and Prof amp; Aacute; coding of these compounds, pharmacological synthesis and amp; eacute; pins of these compounds, as well as the use of these compounds in treatment and prevention; oacute; n refers to im amp; eacute; eacute; dics and disorders, M amp; Aacute; S mainly through inhibition and amp; oacute; n de nrp3. lt; P gt;<;p>;LA PRESENTE INVENCIÓ;N SE REFIERE A COMPUESTOS DE LA FÓ;RMULA (I), DONDE Q SE SELECCIONA DE O O S; R1 ES UN GRUPO HETEROCÍ;CLICO NO AROMÁ;TICO QUE COMPRENDE AL MENOS UN Á;TOMO DE NITRÓ;GENO DE ANILLO, DONDE R1 SE ENLAZA AL Á;TOMO DE AZUFRE DEL GRUPO SULFONILUREA MEDIANTE UN Á;TOMO DE CARBONO DE ANILLO Y DONDE R1 PUEDE SUSTITUIRSE OPCIONALMENTE; Y R2 ES UN GRUPO CÍ;CLICO SUSTITUIDO EN LA POSICIÓ;N &Alpha;, DONDE R2 PUEDE SUSTITUIRSE OPCIONALMENTE DE FORMA ADICIONAL. LA PRESENTE INVENCIÓ;N SE REFIERE ADEMÁ;S A SALES, SOLVATOS Y PROFÁ;RMACOS DE DICHOS COMPUESTOS, A COMPOSICIONES FARMACÉ;UTICAS DE DICHOS COMPUESTOS, Y AL USO DE DICHOS COMPUESTOS EN EL TRATAMIENTO Y LA PREVENCIÓ;N DE TRASTORNOS MÉ;DICOS Y ENFERMEDADES, MÁ;S PARTICULARMENTE MEDIANTE LA INHIBICIÓ;N DE NLRP3.<;/p>;