A toothbrush head, including at least one two-component cleaning element and at least one bristle tuft element, is produced by injection molding. To achieve high design flexibility regarding the arrangement of the two-component cleaning elements and regarding the material choice, the two-component cleaning elements are manufactured separately or in an upstream molding step. Then the two-component cleaning elements, together with the bristle tufts, are over-molded with plastic material, to form the brush head or a part thereof.