LIQUID FORMULATIONS OF SALTS OF 1-[2-(2,4-DIMETHYLPHENYLSULFANYL)PHENYL]PIPERAZINE

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专利权人:

H. LUNDBECK A/S

发明人:

TREPPENDAHL, SVEND,LOPEZ DE DIEGO, HEIDI

申请号：

NZ59643110

公开号：

NZ596431A

申请日:

2010.04.16

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

The compound 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (compound I) has been disclosed in WO 03/029232 as the free base. The present disclosure is directed to the finding that the L-lactic acid addition salt (=L-lactate), the D-lactic acid addition salt (=D-lactate) and the DL-lactic acid addition salt (=DL-lactate) of 1-[2-(2,4dimethylphenylsulfanyl)phenyl]piperazine are highly soluble whereas the usefulness of other known forms is compromised by poor solubility.

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