PFIZENMAIER, KLAUS,WAJANT, HARALD,MOOSMAYER, DIETER,WUEEST, THOMAS
申请号：
EP01984646.8
公开号：
EP1317488B1
申请日:
2001.09.07
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
Subject matter of the invention are antibody-cytokine fusion proteins having proapoptotic and immune modulating properties, but wherein the cytokine moiety a priori has a bioactivity which is very low or restricted to certain receptor subtypes. These reagent exert their full biological activity via the corresponding cytokine receptor(s) only after antibody-mediated binding of the fusion protein to a specific cell membrane-expressed target molecule. By suitable choice of the antibody specificity, the cytokine activity is directed to the tissue, e.g. tumor tissue, to be treated, and a therapeutic agent can be produced being specifically designed/optimized for the respective indication/tumor entity.
