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TEXAPHYRIN AND ANTITUMOR ANTIBIOTIC CONJUGATES
专利权人:
BOARD OF REGENTS; THE UNIVERSITY OF TEXAS SYSTEM
发明人:
Jonathan L. SESSLER,Min Hee LEE
申请号:
US16338992
公开号:
US20190231888A1
申请日:
2017.10.03
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present disclosure relates to texaphyrin compounds linked with an antitumor antibiotic such as an anthcyanine antitumor antibiotic such as doxorubicin and danurubicin. The texaphyrin and the antitumor antibiotic are joined together by a group which is cleavable in vivo and results in increased activity and deliverance of the cytotoxic compound to target cells. Also provided herein are pharmaceutical compositions and methods of use thereof.
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