The Johns Hopkins University; as represented by the Secretary;The Government of the United States of America; Department of Health and Human Services;The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services
发明人:
Gambhira, Ratish,Roden, Richard B. S.,Schiller, John T.,Pastrana, Diana V.,Lowy, Douglas R.
申请号：
AU2006210792
公开号：
AU2006210792B2
申请日:
2006.02.01
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention comprises a method for inducing broadly cross-neutralizing antibodiesagainst cutaneous and mucosal papillomavirus types or against heterologouspapillomavirus types in humans comprising administering to a human in need thereofan immunogenic peptide or protein (or polynucleotide encoding therefor), wherethe immunogenic peptide or protein is: (a) a peptide or protein of at least 10 aminoacid residues in length having a sequence corresponding to either a sequencefrom the N terminal amino acids 1-200 of papillomavirus L2 protein (for cross-neutralizingantibodies against cutaneous and mucosal papillomavirus types) or a sequencefrom the N terminal amino acids 1-88 of papillomavirus L2 protein (for cross-neutralizingantibodies against heterologous papillomavirus types), (b) a peptide or proteinof at least 10 amino acid residues in length with at least 55% identity with thesequence from (a), or (c) a peptide or protein as defined in either (a) or (b) whichis conjugated or fused to a protein or peptide other than a papillomavirus L2 proteinor peptide.
