Piperidine derivatives as orexin receptor antagonist农业专利-农业学术服务平台

发明人:: HE, HAI-YING,贺海鹰,賀海鷹,WU, SONG-LIANG,吴松亮,吳松亮,ZHANG, YANG,张杨,張楊,MA, BIAO,马彪,馬彪,CHEN, YUAN,陈远,陳遠,WANG, YU-HE,王玉贺,王玉賀,CHEN, SHU-HUI,陈曙辉,陳曙輝,LU, QIANG,吕强,呂強,LAN, JIONG,兰炯,蘭炯,LIU, XING,刘星,劉星

摘要：: The present invention discloses a series of piperidine derivatives as orexin receptor antagonists and compositions thereof, and relates to the application thereof in preparing medications for the treatment of insomnia, chronic obstructive pulmonary disease, obstructive sleep apnea, hypersomnia, anxiety, obsessive-compulsive disorder, panic attack, nicotine addiction, or binge eating disorder.本發明公開了一系列作為食慾激素受體拮抗劑的呱啶衍生物及其組合物,並涉及其在製備治療失眠、慢性阻塞性肺病、阻塞性睡眠呼吸暫停、嗜睡、焦慮、強迫、恐慌、尼古丁依賴或飲食混亂障礙的藥物中的應用藥物中的用途。無。