Hasler, Julien,Rutkowski, Julia Lynn,Wicher, Krzysztof Bartlomiej
申请号：
AU2015346045
公开号：
AU2015346045A1
申请日:
2015.11.16
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
This invention relates TfR-specific binding moieties with high specificity for and functional interaction with the transferrin receptor ("TfR"). These moieties may be used to carry biomolecules across membranes, including the blood brain barrier and the gastrointestinal tract. The invention relates more specifically to nurse shark VNAR single chain antibodies that bind to TfR, conjugates and compositions comprising a TfR specific VNAR binding moiety, methods for preparing them, diagnostic and therapeutic methods of use
