PHOSPHORAMIDITE DERIVATIVES OF GEMCITABINE FOR USE IN THE TREATMENT CANCER

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专利权人:

发明人:

申请号：

EP11771265.3

公开号：

EP2625187B1

申请日:

2011.10.05

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

Phosphorodiamidate derivatives of e.g. gemcitabine are provided for use in treating cancer. In one embodiment, the two amidate motifs each comprises NR&primeR&Prime where R&prime is H and R&Prime is CR5R6CO2R7, where R6 is H, R5 is the side chain, including H and C1, of a naturally occurring alpha amino acid, and R7 is branched or unbranched, substituted or unsubstituted, acyclic or cyclic alkyl, including t-butyl-CH2-, benzyl and C3 to C6 cycloalkyl. Formula (I).

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