Soluble inhibitors of vascular endothelial growth factor and use thereof

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专利权人:

Michael Klagsbrun;Shay Soker;Michael L. Gagnon

发明人:

Michael Klagsbrun,Shay Soker,Michael L. Gagnon

申请号：

US12756737

公开号：

US08529905B2

申请日:

2010.04.08

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention relates to cDNA encoding a soluble neuropilin protein (sNP) which is isolated from neuropilin (NP) producing cells or is recombinantly engineered from NP-encoding DNA. NP-1 and NP-2 are preferred NPs but any neuropilin or VEGF receptor (VEGFR), where the constituents share at least about 85% homology with either of the above VEGF165R/NP-1 and NP-2. More preferably, such constituent shares at least 90% homology. Still more preferably, each constituent shares at least 95% homology.

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