A unit dose dry powder inhaler (400) includes a base (428) defining a capsule seat (430) that holds a capsule (434) of medicament and an air intake (436) that is in fluid communication with the capsule seat. The intake draws air into the capsule seat to generate rapid capsule precession and centrifugal forces that fluidize and disperse powder agglomerates. Entrained powder is drawn through a grid (412) to disperse powder agglomerates via impaction forces. An inlet funnel (404) between the grid and a dispersion chamber (406) tapers to a small inlet orifice (410) into the dispersion chamber to disperse powder agglomerates via shear forces generated at the orifice. The chamber entrains powder from the inlet funnel and holds an actuator (416) that oscillates during inhalation to disperse powder agglomerates by dynamic impaction with the actuator and increased turbulence within the chamber. A tapered outlet funnel (408) reduces particle velocity and turbulence and provides an exit for air and aerosolized medicament.
