An ultrasound sensing guidance system employing a medical tool (30) including an ultrasonic motor (40) for actuating the medical tool (30) relative to an anatomical region. The ultrasound sensing guidance system further employs an ultrasound transducer (50) and an ultrasound sensing guidance controller (70). In operation, the ultrasound transducer (50) generates acoustic sensing data indicative of a sensing by the ultrasound transducer (50) of an acoustic wave emitted by the ultrasonic motor (40) as the ultrasonic motor (40) actuates the medical tool (30) relative to the anatomical region, and the ultrasound sensing guidance controller (70) controls an actuation of the medical tool (30) by the ultrasonic motor (40) responsive to the generation of the acoustic sensing data by the ultrasound transducer (50).