No Soo Kim,Jong-Shik Park,Jin-Mu Yi,You Jin Lee,Eun-Sang Cho,Jinhee Kim,Chae Jun Lim,Ok-Sun Bang,Youngah Kim
申请号：
US15572062
公开号：
US10517913B2
申请日:
2015.09.30
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A composition comprising a Lithospermi Radix extract as an effective component prevents, alleviates, or treats peripheral neuropathy, in particular, peripheral neuropathy induced by an anti-cancer agent (i.e., chemotherapy-induced peripheral neuropathy). A method for preventing or treating peripheral neuropathy includes administering to a subject in need thereof the composition. The Lithospermi Radix extract can relieve the suppressed growth of neurites caused by an anti-cancer agent while neither inducing any cytotoxicity in normal cells nor changing the unique cytotoxic potential of an anti-cancer agent in human cancer cells. In addition, the Lithospermi Radix extract can efficiently lower the enhanced sensitivity to painful stimuli in peripheral neuropathic animals induced by an anti-cancer agent. Thus, the Lithospermi Radix extract can be advantageously used as an effective component of a composition for prevention, alleviation, or treatment of chemotherapy-induced peripheral neuropathy.
