PROBLEM TO BE SOLVED: To provide a method for producing a cationic liposomal preparation comprising a lipophilic active compound with improved physical and chemical stability and pharmaceutical acceptability.SOLUTION: The method for producing a cationic liposomal preparation comprising at least one amphiphile selected from cationic lipids of at least about 30 mol%, optionally at least one other amphiphile of up to about 69.9 mol%, a lipophilic active compound of at least about 0.1 mol% and a stabilizing agent of about 0. 1-20% (m/v), comprises steps of preparing an organic solution comprising an organic solvent, the active compound and the cationic lipid, and optionally the other amphiphile, and an aqueous solution comprising the stabilizing agent producing a cationic liposomal preparation from the solution optionally homogenising the preparation at least once and/or optionally sterilizing and filtrating the preparation and dehydrating the preparation and optionally reconstituting the cationic liposomes in an aqueous solution.
