SCHONTHAL, AXEL H.,PETASIS, NICOS A.,HOFMAN, FLORENCE M.,LOUIE, STAN G.,CHEN, THOMAS C.
申请号：
MYPI 20094039
公开号：
MY151089A
申请日:
2008.03.26
申请国别(地区):
MY
年份:
2014
代理人:
摘要：
THE PRESENT INVENTION PROVIDES A METHOD FOR INDUCING APOPTOSIS IN SELECTED CELLS BY AGGRAVATING ER-STRESS. THE AGGRAVATION OF ER-STRESS IS ACHIEVED IN A SPECIFIC MANNER BY INHIBITING SERCA (SARCOPLASMIC/ENDOPLASMIC RETICULUM CALCIUM ATPASE), LEADING TO ELEVATED LEVEL OF CYTOPLASMIC CALCIUM CONCENTRATION, YET WITHOUT INHIBITING THE ACTIVITY OF COX-2 (CYCLOOXYGENASE-2) OR TRIGGERING THE RELEASE OF HISTAMINE. INDUCTION OF APOPTOSIS MAY BE ENHANCED BY FIRST INDUCING OR FURTHER AGGRAVATING ER-STRESS THROUGH INHIBITION OF PROTEASOME OR PROTEASES. ALSO PROVIDED ARE COMPOUNDS AND COMPOSITIONS USEFUL AS ER-STRESS AGGRAVATING AGENTS, METHODS FOR SCREENING, SELECTING, IDENTIFYING AND DESIGNING THE SAME AND METHODS FOR TREATING DISEASED CONDITIONS BY INDUCING APOPTOSIS THROUGH SPECIFIC AND SELECTIVE AGGRAVATION OF ER-STRESS. FIGURE 4.
