PROBLEM TO BE SOLVED: To provide a granular agent that has masked a bitter taste and a disagreeable taste of a galenical ingredient contained therein such as Geranium thunbergii, Geranium thunbergii extract, Geranium thunbergii extract powder, Scopolia extract, Scopolia extract powder, or the like though rapidly disintegrating in the oral cavity, and an intraorally rapidly disintegrating tablet containing the same.SOLUTION: The granular agent is obtained by a step (step 1) where Geranium thunbergii extract powder, three-time diluted Scopolia extract and cyclodextrin are ground and mixed together by means of a grinding and mixing machine to give ground matter composed of ground particles of the Geranium thunbergii extract powder, the three-time diluted Scopolia extract and cyclodextrin mutually adhered and a step (step 2) where the ground and mixed matter manufactured in step 1, a binding agent (hydroxypropylcellulose) and anhydrous ethanol are mixed, kneaded and granulated together to give a granule and subsequently the thus-obtained granule is sieved and dried. The intraorally rapidly disintegrating tablet comprises the granular agent.COPYRIGHT: (C)2012,JPO&INPIT【課題】口腔内で速やかに崩壊するにもかかわらず、含有するゲンノショウコ、ゲンノショウコエキス、ゲンノショウコエキス末、ロートエキス、ロートエキス末等の生薬成分の苦味・不快味がマスキングされた顆粒剤、及びそれを含有する口腔内速崩壊錠を提供すること。【解決手段】ゲンノショウコエキス末、ロートエキス3倍散とシクロデキストリン類を、粉砕混合機を使用して粉砕混合し、ゲンノショウコエキス末、ロートエキス3倍散、シクロデキストリン類の粉砕粒子が互いに付着した粉砕品を得る工程(工程1)と、上記工程1で製造した粉砕混合品、結合剤(ヒドロキシプロピルセルロース)、及び無水エタノールを、混合、練合、造粒し、次いで、得られた造粒物を篩過し、乾燥すること(工程2)により得られる顆粒剤、この顆粒剤を配合した口腔内速崩壊錠である。【選択図】 図3
