A polymeric web exhibiting a soft and silky tactile impression on at least one side thereof is disclosed. The silky feeling side of the web exhibits a pattern of discrete hair-like fibrils, each of the hair-like fibrils being a protruded extension of the web surface and having a side wall defining an open proximal portion and a closed distal portion. The hair-like fibrils exhibit a maximum lateral cross-sectional diameter of between 2 and 5 mils, and an aspect ratio from 1 to 3. Methods and apparatus for making the polymeric web utilize a three-dimensional forming structure having a plurality of protrusions being generally columnar forms having an average aspect ratio of at least about 1.Forbindelse med formel I hvori Rl, R2, R3 og Y er som definert heri, eller en farmasøytisk akseptabel og spaltbar ester, eller syreaddisjonssalt derav, anvendelig for å fremme frigivelse av paratyroidhormon, for eksempel for å hindre eller behandle bentilstander som er assosiert med kalsiumutmagring eller resorpsjon eller hvori stimulering av bendannelse og kalsiumfiksering i benet er ønskelig.
