A method for increasing susceptibility of microorganisms to antibiotics includes providing a microorganism； administering an antibiotic including a nitro-containing amphenicol compound to the microorganism； and administering any of an uronic, aldonic, ulosonic, and aldaric feedstock to the microorganism. The feedstock is adapted to promote cell metabolism, and inhibit antibiotic inactivation pathways in the microorganism causing increased sensitivity of the microorganism to the nitro-containing amphenicol.
