J. Silvio Gutkind,Ramiro Iglesias-Bartolome,Vyomesh Patel,Ana p. Cotrim,Alfredo Molinolo,James B. Mitchell
申请号：
US13798863
公开号：
US09278090B2
申请日:
2013.03.13
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed is a method of preventing the development of mucositis in a subject undergoing radiation therapy or chemotherapy for a disease in need thereof comprising administering an effective amount of a mammalian target of rapamycin (mTOR) inhibitor, such as rapamycin, to the subject. Further disclosed is a method of increasing the lifespan of a normal oral keratinocyte and/or reducing oxidative stress in a normal epithelial cell, wherein the method comprises administering an effective amount of an mTOR inhibitor to a subject undergoing radiation therapy or chemotherapy for a disease in need thereof.
