The method of bright 1 compound of Ti Gong System Prepare formula of this Hair, use the compound of the Suo Fang of stating Fa System Prepare formula 5, or its Lin Suan Which, Liu Suan Which, sulfuric acid Hydrogen Which, Ping Guo Suan Which, Lemon Meng Suan Which, Jiu Shi Suan Which or Fu Ma Suan Which and Fu Ma Suan Which are controlling the purposes in Treatment Group conjunction object with what.本發明提供了製備式1化合物的方法,使用所述方法製備式5的化合物,或其磷酸鹽、硫酸鹽、硫酸氫鹽、蘋果酸鹽、檸檬酸鹽、酒石酸鹽或富馬酸鹽,和富馬酸鹽在用於治療的組合物中的用途。