GlaxoSmithKline Biologicals S.A.;Icahn School of Medicine at Mount Sinai
发明人:
KRAMMER, Florian,PALESE, Peter,GARCIA-SASTRE, Adolfo,NACHBAGAUER, Raffael,INNIS, Bruce,MALLETT, Corey Patrick
申请号：
EP17807489
公开号：
EP3463447A4
申请日:
2017.06.01
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Provided herein are immunization regimens for inducing an immune response (e.g., and antibody response) against influenza virus. In specific aspects, the immunization regimens involve the administration of a chimeric hemagglutinin (HA), a headless HA or another influenza virus stem domain based construct (e.g., the HA stem domain or a fragment thereof) to a subject. In certain aspects, the immunization regimens also involve the administration of an influenza virus neuraminidase immunogen. Also provided herein are immunogenic/vaccine compositions for use in methods of immunizing or immunization regimens for human subjects against influenza virus.
