PLATEFORME TRANS-REGNE D'ADMINISTRATION D'ACIDES NUCLEIQUES THERAPEUTIQUES

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专利权人:

SIVEC BIOTECHNOLOGIES; LLC

发明人:

LINKE, LYNDSEY M.,MORA, DARCY

申请号：

CA3058474

公开号：

CA3058474A1

申请日:

2018.04.03

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

A transkingdom platform for the delivery of therapeutic nucleic acids toepithelial tissues where the nucleic acids aredesigned to have enhanced stability. The platform offers numerous improvementsto prior delivery platforms including expression ofthe double-stranded RNA binding domain (dsRBD) domains of TAR RNA bindingprotein (TRBP), knockout of RNase R activityin the bacterial delivery vehicle, and expression of the methyltransferasegene, HEN1, for simultaneous packaging with a therapeuticnucleic acid delivery vehicle.

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