A kit for forming a bioerodible composition is provided with a first aliquot portion of a reaction mixture having an aldehydic polymer solution, and a second aliquot portion of a reaction mixture having solids which include a cross-linking hydrazide. When mixed, the first and second aliquot portions of the reaction mixture react at a pH of 4 to 6 to form a solidified bioerodible composition within about 1 to about 10 minutes, to form a hydrazide cross-linked aldehydic polymer matrix. The bioerodable composition may be usefully employed to seal and/or treat wounds (e.g., a surgical incision).
