Described is an autoinjector (1) comprising a case (2.1, 2.2), a drive carriage (22) disposed in the case (2.1, 2.2), and a plunger (11) coupled to the drive carriage (22). The plunger (11) is adapted to releasably engage a needle retraction mechanism in a syringe (3). Translation of the drive carriage (22) in a distal direction (D) relative to the case (2.1, 2.2) causes the plunger (11) to engage the needle retraction mechanism and translation of the drive carriage (22) in a proximal direction (P) relative to the casing (2.1, 2.2) case the plunger (11) to needle retraction mechanism the stopper (5).