An ultrasound imaging system (102) includes a touch screen user interface (122) and a touch screen controller (148). The touch screen user interface includes a touch panel (124). The touch panel includes a plurality of different clusters (510-522) of controls including a first cluster (512) in first sub-region and with a tactile control and one or more other cluster (510 and 514-522) in one or more other different sub-regions and with soft controls. The touch screen controller visually renders the one or more other clusters in the one or more different sub-regions spatially arranged with respect to each other based on a predetermined control cluster configuration for the touch screen user interface. The one or more other clusters include controls that correspond to different groupings of ultrasound imaging operations of the ultrasound imaging system.