6.7-Dialcoxi-3-isoquinol substitutes, PDE10A inhibitors； synthesis of pharmaceuticals containing these substances； and compounds used to treat metabolic disorders, SNC disorders, such as Alzheimer's disease, depression and neurodegenerative disorders They are multiple sclerosis.
DONELLO JOHN E,YANG RONG,LEBLOND BERTRAND,BEAUSOLEIL ERIC,CASAGRANDE ANNE-SOPHIE,DESIRE LAURENT J.R.,PANDO MATTHEW P,CHAUVIGNAC CEDRIC,TAVERNE THIERRY
申请号：
CL2013002394
公开号：
CL2013002394A1
申请日:
2013.08.19
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The invention relates to compounds of the formula wherein R&prime；, R1, through R7 and Ar are as defined herein. These compounds are useful as inhibitors of phosphodiesterase 10 (PDE10A) which are useful in treating central nervous system diseases such as psychosis and also in treating, for example, obesity, type II diabetes, metabolic syndrome, glucose intolerance, pain and ophthalmic diseases.COMPUESTOS DERIVADOS DE 6,7-DIALCOXI-3-ISOQUINOLINOL SUSTITUIDOS, INHIBIDORES DE LA PDE10A； COMPOSICION FARMACEUTICA QUE LOS COMPRENDE； Y SU USO EN EL TRATAMIENTO DE TRASTORNOS METABOLICOS, TRASTORNOS DEL SNC TALES COMO ENFERMEDAD DE ALZHEIMER, DEMENCIA, DEPRESION Y TRASTORNOS NEURODEGENERATIVOS TALES COMO ESCLEROSIS MULTIPLE, ENTRE OTROS.
