The Trustees of Columbia University in The City of New York
发明人:
Jonathan BARASCH,Neal PARAGAS
申请号：
US14794347
公开号：
US20160136237A1
申请日:
2015.07.08
申请国别(地区):
US
年份:
2016
代理人:
摘要：
In some embodiments, the present invention is directed to compositions and methods for the treatment and prevention of urinary tract infections (UTIs) and urosepsis. In some embodiments, the methods of the invention comprise administering to a subject in need thereof a therapeutically effective amount of an agent that stimulates genito-urinary tract epithelial cells to produce NGAL, and/or an NGAL protein or a functional derivative thereof, and optionally also administering to the subject an additional agent useful for treating or preventing UTI or urosepsis. In other embodiments, the present invention also provides methods of screening for agents that stimulate urinary tract epithelial cells to produce NGAL.
