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Process of Evaluating Blood-Brain Barrier Permeability of Stroke Rat by Using Fluorescent Substance
专利权人:
Jun-Ming Shih
发明人:
Jun-Ming Shih,Yuan-Ruei Huang,Yu-Lung Wu,Shih-Ying Lee,Kang-Wei Chang,Chia-Chien Chen
申请号:
US13545238
公开号:
US20140017173A1
申请日:
2012.07.10
申请国别(地区):
US
年份:
2014
代理人:
摘要:
A process of evaluating blood-brain barrier permeability of a stroke rat by using fluorescent substance is disclosed. This process uses an Evans blue dye having spontaneous fluorescence properties, in combination with the use of a new non-invasive in vivo imaging system (IVIS), to obtain fluorescent signals so as to assess the change in the blood-brain barrier permeability of rodents after a cerebral artery stroke model surgery. In operation, an Evans blue dye is injected into a stroke rat of middle cerebral artery occlusion model. A non-invasive in vivo imaging system is used to detect the fluorescence distribution of the whole brain, and obtain images combined by the fluorescence images and optical images for the whole brain tissue. Thereby, the change in the blood-brain barrier permeability of the stroke rat can be completely realized.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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