LUBRIS, LLC;Rhode Island Hospital, a Lifespan-Partner
发明人:
Gregory, D. JAY,Benjamin, D. SULLIVAN,Tannin, Avery SCHMIDT,Khaled ELSAID,Edward, R. TRUITT,Roman KRAWETZ,Joanna SZMYDYNGER-CHODOBSKA,Adam CHODOBSKA,Jawed FAREED
申请号：
HK18107350
公开号：
HK1247834A1
申请日:
2018.06.05
申请国别(地区):
HK
年份:
2018
代理人:
摘要：
Disclosed herein are methods of using PRG4 glycoprotein, also known as lubricin, to reduce, inhibit, or down-regulate pro-inflammatory pathways in patients at risk of or suffering from an inflammatory response or allergy symptom through CD44 antagonization, regulating pro-inflammatory cytokine production, inhibiting NF-κB translocation and/or facilitating removal of inflammation-inducing cellular or matrix debris or allergens.
