A cannula seal is presented. The cannula seal includes a cap portion that fits over a cannula and a valve portion. The valve portion includes an hourglass seal and a cross slit seal. In some embodiments, the cap portion includes a tab. In some embodiments, the cap portion and the valve portion are integrally formed. In some embodiments, the cap portion and the valve portion are joined at a bonding region, which may include overflow traps. In some embodiments, ribs are included.