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Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
专利权人:
PFIZER INC.
发明人:
MASCITTI VINCENT
申请号:
NZ59994510
公开号:
NZ599945A
申请日:
2010.10.21
申请国别(地区):
NZ
年份:
2014
代理人:
摘要:
599945 Compounds of Formula (A) and (B) are described herein and the uses thereof for the treatment of diseases, conditions and/or disorders mediated by sodium-glucose transporter inhibitors (in particular, SGLT2 inhibitors). Examples of the compounds are: (1S,2S,3S,4R,5S)-5-[4-chloro-3-(4-hydroxy-benzyl)-phenyl]-1-hydroxymethyl-6,8-dioxa-bicyclo[3.2.1]octane-2,3,4-triol; (1S,2S ,3S ,4R,5S )-5-{ 4-chloro-3-[( 4-ethoxy-phenyl)-hydroxy-methyl]phenyl} -1-hydroxymethyl-6,8-dioxa-bicyclo[3.2.1]octane-2,3,4-triol and Acetic acid 2-{ 4-[2-chloro-5-((1 S,2S,3S,4R,5S)-2,3,4-trihydroxy-1-hydroxymethyl-6,8-dioxa-bicyclo[3.2.1]oct-5-yl)-benzyl]-phenoxy} -ethyl ester.
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