Martin PULE,Kwee YONG,Lydia LEE,Neil CHAPLIN,Ben DRAPER
申请号：
US15121644
公开号：
US20160362467A1
申请日:
2015.02.26
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides a variant proliferation-inducing ligand (APRIL), which has a higher binding affinity to BCMA than wild-type APRIL； and/or altered binding kinetics compared with wild-type APRIL, and/or a higher BCMA:TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) binding ratio than wild-type APRIL and which comprises mutations at one or more of the following positions: A125, V174, T175, M200, P201, S202, H203, D205 and R206.
