University Pittsburgh - Of the Commonwealth System of Higher Education
发明人:
Arvydas Usas,Karin Payne,Thomas Payne,Ronald Jankowski,Johnny Huard
申请号：
US16293041
公开号：
US20200000966A1
申请日:
2019.03.05
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
