A MEDICAMENT DELIVERY DEVICE (1) COMPRISES AN ACTUATION MECHANISM BY SUCCESSIVE OPERATION OF WHICH A PREDETERMINED NUMBER OF UNIT DOSES OF MEDICAMENT CAN BE DISPENSED. THE DEVICE INCLUDES A LOCKING MECHANISM FOR PREVENTING FURTHER OPERATION OF THE ACTUATION MECHANISM AFTER DISPENSING OF SAID PREDETERMINED NUMBER OF UNIT DOSES. THE LOCKING MECHANISM COMPRISES A RESILIENT MEMBER (51), A FORMATION (18) WITH WHICH THE RESILIENT MEMBER (51) IS ENGAGEABLE TO DISABLE OPERATION OF THE ACTUATION MECHANISM, AND A BARRIER MEMBER (20) THAT PREVENTS ENGAGEMENT OF THE RESILIENT MEMBER (51) AND THE FORMATION (18) UNTIL SAID PREDETERMINED NUMBER OF UNIT DOSES HAS BEEN DISPENSED. THE DEVICE (1) MAY BE A DRY POWDER INHALER. FIGURE 3