Systems and methods for intraocular lens (IOL) selection using emmetropia zone prediction include determining pre-operative measurements of an eye, estimating a post-operative anterior chamber depth (ACD) of an intraocular lens based on the pre-operative measurements, estimating a post-operative manifest refraction in spherical equivalent (MRSE) of the eye with the IOL implanted based on the pre-operative measurements and the estimated post-operative ACD, determining whether the eye with the IOL implanted is likely to be in an emmetropia zone based on the estimated post-operative MRSE, re-estimating the post-operative MRSE of the eye with the IOL implanted using an emmetropia zone prediction model or a non-emmetropia zone prediction model based on the emmetropia zone determining, and providing the re-estimated post-operative MRSE to a user to aid in selection of an IOL for implantation in the eye.
