The Trustees of Columbia University in the City of New York;U.S. Army Edgewood Chemical Biological Center
发明人:
Kathryn Louise Killops,Luis M. Campos,Spencer D. Brucks
申请号：
US15502665
公开号：
US20170226246A1
申请日:
2015.08.07
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Embodiments of the present invention provides compounds, compositions, and methods for their preparation or synthesis that provide polymer-based cationic particles, such as, e.g., polymer-nucleic acid complexes, for delivering molecules including biomolecules, which is particularly desirable in gene therapy. Inventive materials include positively-charged linear homopolymers and block copolymers by living free radical polymerization, and polymer-based particles by emulsion polymerization. These polymers and particles may be conjugated with a wide range of biomolecules, and may deliver molecules, including, drug molecules, contrast agents, dyes, and the like, by loading them into the interior of the particles prior to polymerization. These conjugated and/or labeled polymers and particles may be delivered to cells to administer their cargo and achieve a therapeutic response. Additional embodiments may be directed to the methods of synthesizing and using the compounds and compositions, as well as kits comprising the compounds, compositions, and formulations, and desired molecules for delivery.
