Walter Francis Prouty, Jr.,Joseph Vincent Rinella, Jr.
申请号：
US13458057
公开号：
US08268780B2
申请日:
2012.04.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueous solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemization of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.
