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Prodrugs of NRF2 Activating Compounds and Uses Thereof
专利权人:
Rigel Pharmaceuticals; Inc.
发明人:
Jiaxin Yu,Beth Fernandez,Gary Park,Ihab Darwish
申请号:
US16412217
公开号:
US20190367472A1
申请日:
2019.05.14
申请国别(地区):
US
年份:
2019
代理人:
摘要:
Aspects of the present disclosure include prodrugs of compounds that activate Nrf2. Such prodrugs find use in the treatment of autoimmune and inflammatory diseases and disorders, such as for example psoriasis and multiple sclerosis. Embodiments of the present disclosure also relate to pharmaceutical compositions that include these prodrugs, methods of using these prodrugs in the treatment of various diseases and disorders, processes for preparing these prodrugs and intermediates useful in these processes.
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