Provided is a method of treating a cancer patient comprising administering to a patient an effective amount of a MEK inhibitor and an effective amount of a PI3K inhibitor. Also described are compositions in which a MEK inhibitor and a PI3K inhibitor are combined.患者に有効量のMEK阻害剤及び有効量のPI3K阻害剤を投与する工程を含む、癌患者を治療する方法を提供する。MEK阻害剤及びPI3K阻害剤が組み合わされた組成物も記載する。