delayed release drug formulation and method for producing a delayed release drug formulation

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专利权人:

TILLOTTS PHARMA AG

发明人:

Abdul Waseh Basit,Ana Cristina Freire,Felipe José Oliveria Varum,Frédéric Jean-Claude Goutte,Roberto Carlos Bravo González,Thomas Buser

申请号：

BR112014026933

公开号：

BR112014026933A2

申请日:

2013.04.29

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

1/1 summary “delayed release drug formulation, and method to produce a delayed release drug formulation” delayed release of a drug to the colon It is obtained from a delayed release formulation comprising a core and a core coating. the core comprises a drug and the coating comprises an inner layer and an outer layer. the outer layer comprises a mixture of a first polymeric material that is susceptible to attack by colonic bacteria, and a second polymeric material that has a ph threshold around or above ph 5. the inner layer comprises a third polymeric material that is soluble in intestinal fluid or gastrointestinal fluid, said third polymeric material being selected from an at least partially neutralized polycarboxylic acid and a nonionic polymer. In embodiments wherein the third polymeric material is a nonionic polymer, the inner layer comprises at least one of a buffering agent and a base. Advantages of formulations according to the present invention include accelerated release of the drug when exposed to colonic conditions and reduction or elimination of an effect. of food and / or alcohol on drug release after administration.1 / 1 resumo “formulaã‡ãƒo de droga de liberaã‡ãƒo retardada, e, mã‰todo para produzir uma formulaã‡ãƒo de droga de liberaã‡ãƒo retardadaâ€� a liberaã§ã£o retardada de um droga ao cã³lon ã© obtida a partir de uma formulaã§ã£o de liberaã§ã£o retardada que compreende um nãºcleo e um revestimento para o nãºcleo. o nãºcleo compreende um droga e o revestimento compreende uma camada interna e uma camada externa. a camada externa compreende uma mistura de um primeiro material polimã©rico que ã© susceptã­vel ao ataque pelas bactã©rias colã´nicas, e um segundo material polimã©rico que tem um limiar de ph em torno do ph 5 ou acima. a camada interna compreende um terceiro material polimã©rico que ã© solãºvel no fluã­do intestinal ou fluã­do gastrointestinal, o dito terceiro material polimã©rico sendo selecionado de um ã¡cido policarboxã­lico pelo men

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