PROBLEM TO BE SOLVED: To provide a compound having 11β-HSD1 inhibitory activity, and to provide a therapeutic drug of a novel mechanism for diabetes having a reduced side effect, and to provide an improving drug having insulin resistance.SOLUTION: There is provided a heterocyclic compound represented by general formula (I) or its pharmaceutically acceptable salt, wherein R1 represents 1-6C alkyl, 3-10C cycloalkyl, aryl having 6-10 ring constituting carbon atoms, or heteroaryl having 5-10 ring constituting atoms, where the aryl and the heteroaryl may be each independently substituted by 1-6C alkyl or 1-6C alkyloxy, which may be substituted by one or more halogens, or a halogen, R2 to R5 each independently represents 1-6C alkyl or a hydrogen atom, and R6 represents hydroxy or a hydrogen atom.COPYRIGHT: (C)2013,JPO&INPIT【課題】11β-HSD1阻害活性を有する化合物を提供するとともに、副作用が軽減された新たなメカニズムの糖尿病の治療薬及びインスリン抵抗性の改善薬を提供すること。【解決手段】本発明は、下記の一般式で表される複素環化合物又はその薬学的に許容される塩を提供する。【選択図】なし
