Methods and systems are proposed herein for performing manual matching of generated digitally reconstructed radiographs with acquired verification images efficiently without intensive processing and/or memory consumption or hardware requirements. According to one aspect of the claimed subject matter, a system is provided that includes a computing workstation, communicatively coupled to both a data storage device and an image acquisition device. Real time images acquired by the image acquisition device are presented to the user along with one or more digitally reconstructed radiographs (DRRs)—generated using dynamically selected rendering techniques—from previously acquired image data. The user is able to verify the DRRs as a match to the real time image, or, alternately, to dynamically generate additional DRRs more suitable by actuating a portion of the generated DRR. Based on the user actuation, a new DRR is generated and presented to the user for verification.
