John Robert Savage,Jacob J. Sprague,Ashley Galloway,Geoffrey Hird,Marquita Nicole Lilly,Akihisa Nonoyama,Edward Graham Randles,Benjamin Maynor
申请号：
US16099118
公开号：
US20190209538A1
申请日:
2017.05.05
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A composition to induce analgesia includes a plurality of particles, each particle of the plurality having 40-60 wt % amino amide anesthetic or a pharmaceutically acceptable salt, hydrate, or solvate thereof and 60-40 wt % PLGA polymer including 48:52 to 52:48 molar ratio D,L lactide:glycolide and an inherent viscosity of about 0.16 to 0.24 dL/g at 0.1% w/v in chloroform at 25° C. Each particle includes a non-spherical shape less than 100 μιτι in a broadest dimension, and having a volume of about 13,500 cubic micrometers. The amino amide anesthetic is crystalline and includes 50-70% crystalline form I and 30-50% crystalline form II.
