TRAITEMENT DE L'ARTHRITE RHUMATOIDE AU MOYEN D'ANTICORPS GM CSFR ALPHA

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专利权人:

MEDIMMUNE LIMITED

发明人:

GODWOOD, ALEX,MAGRINI, FABIO

申请号：

CA2851322

公开号：

CA2851322A1

申请日:

2012.10.10

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

Treatment of rheumatoid arthritis (RA) to provide clinical benefit in patients, including decrease in DAS28-CRP by more than 1.2 and/or improvement determined by ACR20, ACR50 or ACR70, comprising administering therapeutic antibody mavrilimumab or other inhibitor targeted to Tyr-Leu-Asp-Phe-Gln motif of granulocyte/macrophage colony stimulating factor receptor alpha (GM-CSFRa). Use of GM-CSFRa inhibitors such as mavrilimumab to enhance clinical benefit in RA patients receiving stable dose of DMARDs, particularly methotrexate.

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