Tunable biodegradable linker molecule for temporary conjugation of components of a drug delivery system and drug delivery system prepared therewith

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专利权人:

クリスタル・デリバリー・ビー・ブイ

发明人:

クリスティアンネ・ヨハンナ・フェルディナント・ライケン,ヨハネス・アナ・ウィルヘルムス・クライトザー,コルネリス・フランシスカス・ファン・ノストラム,ステフェン・ファン・デル・ワル,ウィルヘルムス・エーヴェルハルドゥス・ヘニンク,ロベルトゥス・マティアス・ヨセフ・リスカンプ,イシル・アルティンタス

申请号：

JP2013529089

公开号：

JP5934221B2

申请日:

2011.07.14

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

The present invention relates to a particular class of biodegradable linkers, ensuring transiently stable conjugation of building blocks and/or bioactive compounds into drug delivery systems (DDS), such as DDS based on polymeric micelles or hydrogels. In addition, the present invention relates to compounds, comprising said linkers, such compounds preferably being prodrugs. Further, the invention is directed to the use of said linkers, and especially said biodegradable linkers, in a drug delivery system. Moreover, the invention relates to controlled release system comprising a polymer matrix, capable of releasing an active ingredient, wherein the active ingredient is covalently linked to the polymer molecules of the polymer matrix through said linkers, as well as to a method of synthesizing these linkers and preparing such controlled release systems.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/