The present invention relates generally to the field of pharmaceuticals and cosmetics. More specifically, the present invention pertains to certain N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides of the following formula which are potent modulators (e.g., inhibitors) of an androgen receptor, and which are useful, for example, in therapy, for example, in the treatment of a dermatological disease or disorder； a disease or disorder of the sebaceous gland(s)； acne； hyperseborrhoea； oily skin； seborrhoeic dermatitis； hyperpilosity or hirsutism； atopic dermatitis； or androgenic alopecia； especially acne. The present invention also relates to compositions (e.g., pharmaceutical compositions, cosmetic compositions) comprising the compounds； methods of preparing the compositions； methods of modulating (e.g., inhibiting) an androgen receptor using the compounds and/or compositions； and medical and/or cosmetic use of the compounds and compositions.
